I didn't see this one's context but I found the context behind the "no"
3:21:22 Kirb calls Pippa Pipi, and asks chat what they think of the nickname.
Tenma responds with "no" and Pippa even notes "one of my coworkers popped in to say no" as she herself disapproves
View attachment 26347
I do wonder what the brother was in reference too possible it was during the localization convo when Pip mentioned Onii-chan>brother