It's not bad to have it as your first Alien IP experience but you should definitely watch at least Alien and then likely Aliens. It will give you a greater context of the Xenomorphs and you'll understand a lot of the references.
For context:
Alien: Isolation is pretty much Alien
Aliens: Dark Descent is pretty much Aliens
I've put six hours into the game, and it's honestly a decent game. Has of course that AA quirks and limitations, but I think they did a good job with the gameplay idea.
It has Xcom squad customization, Darkest dungeon trauma/blessings, small scale RTS where you command a squad as one unit, and mechanics where going out fighting isn't always the best. It's a game with challenge too, having to debate if you should engage in a fight, hide and hope you're not found by nearby enemies, extract and come back with a healthier squad, or set traps around the map to distract the enemies. Also leaving and coming back to a map keeps everything you done in it persistent, except for smaller aliens corpses remaining. Like those headcrab things.
The maps/missions are not random generated either, which I think is good for a game like this. I do wish however there was more weapons, character customization options for the marines, and maps. However there's a good amount of content in it already for a non full price game so I can't complain too much.
I do hope they support the game in adding more maps, weapons, mechanics, etc. Cause it has a great foundation.
Also, I love how characters can get damaged in it and lose limbs.
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actually shows it too and later on you can get the limbs amputated for prosthesis. Would recommend for Alien and Xcom fans who like a challenge.