It's not bad to have it as your first Alien IP experience but you should definitely watch at least Alien and then likely Aliens. It will give you a greater context of the Xenomorphs and you'll understand a lot of the references.
For context:
Alien: Isolation is pretty much Alien
Aliens: Dark Descent is pretty much Aliens
I've put six hours into the game, and it's honestly a decent game. Has of course that AA quirks and limitations, but I think they did a good job with the gameplay idea.
It has Xcom squad customization, Darkest dungeon trauma/blessings, small scale RTS where you command a squad as one unit, and mechanics where going out fighting isn't always the best. It's a game with challenge too, having to debate if you should engage in a fight, hide and hope you're not found by nearby enemies, extract and come back with a healthier squad, or set traps around the map to distract the enemies. Also leaving and coming back to a map keeps everything you done in it persistent, except for smaller aliens corpses remaining. Like those headcrab things.
The maps/missions are not random generated either, which I think is good for a game like this. I do wish however there was more weapons, character customization options for the marines, and maps. However there's a good amount of content in it already for a non full price game so I can't complain too much.
I do hope they support the game in adding more maps, weapons, mechanics, etc. Cause it has a great foundation.
Also, I love how characters can get damaged in it and lose limbs.
actually shows it too and later on you can get the limbs amputated for prosthesis. Would recommend for Alien and Xcom fans who like a challenge.