Pippa's making a good point about adult cartoons, and old school Simpsons were best when Homer was a loveable but well meaning dumbass instead of of a Peter Griffin clone. Also, the guy who made Family Guy (Seth Rogan?) is intolerable, when he showed up on Shark Tank to help some guy with his pitch he wouldn't shut the fuck up and it reminds me of this game.
Has there been an adult oriented animation in the west that wasn't comedy or porn though? I feel like anime actually tries to make some adult shows that fall outside of those.